Why is contact inhibition important in cancer




















The EMBO journal. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Chardin P. Function and regulation of Rnd proteins. Nat Rev Mol Cell Biol. RhoE inhibits cell cycle progression and Ras-induced transformation. Small G-protein RhoE is underexpressed in prostate cancer and induces cell cycle arrest and apoptosis. The Prostate. RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line.

Exp Cell Res. The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression. The Journal of biological chemistry.

Current biology : CB. Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells. PloS one. Down-regulation of RhoE is associated with progression and poor prognosis in hepatocellular carcinoma. J Surg Oncol. Cancer Res. Epigenetic modification of RhoE expression in gastric cancer cells. Oncol Rep. J Cell Physiol. Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6.

Nature cell biology. Pinner S and Sahai E. Overexpression of RhoE has a prognostic value in non-small cell lung cancer. Ann Surg Oncol. RhoE promotes metastasis in gastric cancer through a mechanism dependent on enhanced expression of CXCR4. Identification of metastasis-associated genes in prostate cancer by genetic profiling of human prostate cancer cell lines. Anticancer research.

Transcriptional up-regulation of RhoE by hypoxia-inducible factor HIF -1 promotes epithelial to mesenchymal transition of gastric cancer cells during hypoxia. Biochemical and biophysical research communications. RhoE is associated with relapse and prognosis of patients with colorectal cancer. Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions.

RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice. E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27 KIP1. The Journal of cell biology. Reduced E-cadherin expression contributes to the loss of p27kip1-mediated mechanism of contact inhibition in thyroid anaplastic carcinomas.

Blagosklonny MV. Are p27 and p21 cytoplasmic oncoproteins? Cell cycle. Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro. Todaro GJ and Green H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. Kemp CJ. Multistep skin cancer in mice as a model to study the evolution of cancer cells. Seminars in cancer biology. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis.

Genes that mediate breast cancer metastasis to lung. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer. Hanahan, D. The hallmarks of cancer. Cell , 57—70 Mayor, R. Keeping in touch with contact inhibition of locomotion. Trends Cell Biol. McClatchey, A. Contact inhibition of proliferation redux.

Cell Biol. Zhao, B. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. Aragona, M. Cell , — Dupont, S. Nature , —U Wada, K. Hippo pathway regulation by cell morphology and stress fibers. Development , — Yu, F. Hippo pathway in organ size control, tissue homeostasis, and cancer.

Moroishi, T. Cancer 15 , 73—79 Johnson, R. The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment. Mo, J. The Hippo signaling pathway in stem cell biology and cancer.

EMBO Rep. Degenhardt, K. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell.

Karantza-Wadsworth, V. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Rubinsztein, D.

Autophagy 5 , — Pavel, M. CCT complex restricts neuropathogenic protein aggregation via autophagy. Kimura, S. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3 , — Sarkar, S. Complex inhibitory effects of nitric oxide on autophagy.

Cell 43 , 19—32 Bjorkoy, G. Komatsu, M. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Atwal, R. Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.

Narain, Y. Bento, C. Tumaneng, K. Leontieva, O. Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program. Natl Acad. USA , — Hansen, C. Liu, A. Schlegelmilch, K. Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Azzolin, L. Kim, N. E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.

Mori, M. Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer. Avivar-Valderas, A. Oncogene 32 , — Wilkinson, D. Cell 57 , 55—68 Pan, J. They worked specifically in human Schwann cells, which are peripheral nerve cells that produce the insulating myelin around nerves, but the findings should apply to other cancers, Kissil says. The team looked at YAP in the context of cell crowding.

Those will also be important to study further, Kissel says, as well as the interaction of these players in the context of cancer drug resistance. Reference: Hoxha, et al. Cancer Research DOI: CAN This article has been republished from the following materials. Architecture of colonies of a pure strain of fibroblastic sarcomatous cells derived from a dibenzanthracene mouse tumour. Further studies on superinfection of polyoma-induced mouse tumors with polyoma virus in vitro. Canti, R.

Cinematograph demonstration of living cells growing in vitro. Behaviour of normal and malignant connective tissue cells in vitro. Cancer Conf. Vaughan, R.

Movements of epithelial cell sheets in vitro. Cell Sci. Wilbanks, G. The in vitro interaction of intra-epithelial neoplasia, normal epithelium, and fibroblasts from the adult human unterine cervix. Cancer Res. Surface specializations of Fundulus cells and their relation to cell movements during gastrulation. Wilbur, K. Cell movements in the healing of microwounds in vitro. Bereiter-Hahn, J.. Zeitrafferlaufbild-und Teilbildanalyse. Holmes, S. Behavior of ectodermic epithelium of tadpoles when cultivated in plasma.

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The inhibition of chick embryo cell growth by medium obtained from cultures of Rous sarcoma cells. Barski, G.

Regulation of growth and orientation in hamster cells transformed by polyoma virus.



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