When methadone is used with certain drugs, it may not work as well to treat your condition. This is because the amount of methadone in your body may be decreased.
Examples of these drugs include:. You or your pharmacy will have to contact your doctor for a new prescription if you need this medication refilled. You should mix it with 3 to 4 ounces 90 to milliliters of water or citrus fruit juice before you take it.
It takes about a minute to mix. You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include:.
There are restrictions on dispensing methadone for detoxification or maintenance programs. Not every pharmacy can dispense this medication for detoxification and maintenance. Talk to your doctor about where you can get this drug. There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date.
However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Over-the-counter and prescription medications are often used to manage pain.
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Ask your pharmacist about a drug take-back program, or flush the unused medicine down the toilet. If you take methadone for pain: Take the missed dose as soon as you remember, then take your next dose 8 to 12 hours later. If you take methadone for drug addiction: Take your missed dose the next day at the regular time. If you miss your doses for longer than 3 days in a row, call your doctor for instructions. You may need to restart methadone at a lower dose. Seek emergency medical attention or call the Poison Help line at An overdose can be fatal, especially in a child or person using opioid medicine without a prescription.
Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing. Your doctor may recommend you get naloxone a medicine to reverse an opioid overdose and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR cardiopulmonary resuscitation on you while waiting for help to arrive.
Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it. Avoid driving or hazardous activity until you know how this medicine will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries. Grapefruit may interact with methadone and cause side effects. Avoid consuming grapefruit products. Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Opioid medicine can slow or stop your breathing, and death may occur. Serious breathing problems may be more likely in older adults and people who are debilitated or have wasting syndrome or chronic breathing disorders. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may have a fatal methadone overdose if you start or stop using certain other medicines.
Tell your doctor about all your medications. Many other drugs can be dangerous when used with opioid medicine. Methadone Hydrochloride slide 2 of 10, Methadone Hydrochloride,. Methadone Hydrochloride slide 3 of 10, Methadone Hydrochloride,. Dolophine slide 4 of 10, Dolophine,. Methadose slide 5 of 10, Methadose,. Methadone Hydrochloride slide 6 of 10, Methadone Hydrochloride,. Methadose slide 7 of 10, Methadose,.
Methadone Hydrochloride slide 8 of 10, Methadone Hydrochloride,. Methadone Hydrochloride slide 9 of 10, Methadone Hydrochloride,. Methadose slide 10 of 10, Methadose,. What is the most important information I should know about methadone? What is methadone? Methadone is an opioid medication used to treat pain. Methadone is available only from a certified pharmacy. Methadone may also be used for purposes not listed in this medication guide. What should I discuss with my healthcare provider before using methadone?
You should not use methadone if you are allergic to it, or if you have:. How should I use methadone? What happens if I miss a dose? Do not take two doses at one time. What happens if I overdose? What should I avoid while using methadone? Do not drink alcohol. Dangerous side effects or death could occur. What are the possible side effects of methadone? What other drugs will affect methadone?
Where can I get more information? Your doctor or pharmacist can provide more information about methadone. Results: Nasal uptake of methadone was rapid, with maximum plasma concentrations occurring within 7 minutes. The maximum effects of intravenous, nasal, and oral methadone, on the basis of dark-adapted pupil diameter, were reached in about 15 minutes, 30 minutes, and 2 hours, respectively.
The respective durations were 24, 10, and 8 hours. Both nasal and oral bioavailabilities were 0.
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